Full Spectrum Hemp Oil vs CBD Isolate

How do Botanically Complete Formulations Compare with Single Compound Formulations?
Hemp is one of the most versatile plants in the world. It has a long history of use as a food, fuel, fiber and medicine. Many cultures hold deep reverence for its medicinal benefits and flat out healing powers.

In today’s World, the focus has been on only one of hemps many hundreds of active and essential compounds: namely, the primary natural cannabinoid known as cannabidiol (CBD). This CBD-centric focus has led to the development of some excellent products, such as the Epidiolex, a cannabis-derived pharmaceutical drug that is poised to be approved by the FDA for the treatment of pediatric refractory epilepsy. However, CBD alone is only capable of conferring part of hemp’s power — and therein lies the limitation and hubris of using the ‘isolated active ingredient’ model.

The market is currently flooded with companies selling CBD in all kinds of formats: oils, edibles, topical, vaping, transdermal, and more. It’s hard to think that just a couple of years ago, such a thing was unheard of!

As a consumer, however, the need to be informed is key to the unregulated market of CBD, because not all manufactured goods are what they claim to be.   While some are seeking FDA approval for products and regulation is not yet a common idea in the industry, each production company is subject to its own morals and ethics when it comes to labeling and transparency of product ingredients and mg.

Full Spectrum vs Isolate

As the term suggests, full spectrum hemp oil comes with all the of the cannabinoids present in the plant. In hemp oil, this includes a long list of cannabis compounds (400+).  When CBD is in isolate form, it is separated from other cannabis compounds in the source plant.  

It has become typical within some sectors of the nutraceutical industry to emulate the pharmaceutical model, which focuses on identifying a single, well understood molecule that can be standardized and studied to determine its relative safety and efficacy. This focus on the delivery and effectiveness of each purported ‘active ingredient’, within each serving, as if it were a pharmaceutical drug, ignores the holistic benefits of plant based medicine that arise from combining active ingredients with other essential molecules that interact synergistically to produce outcomes that are greater than the sum of each individual molecule or ingredient.

The truth is, there is no singular ‘magic bullet’ in a food or herbal supplement that is responsible for the whole plant’s health benefits.  If you limit your intake to only one compound, expect limited results.  The fact is that most medicinal plants contain hundreds of active compounds which interact synergistically to enhance the health benefits.
Beyond Just “CBD”

In 2015, a groundbreaking study demonstrated the superior therapeutic properties of whole plant hemp extracts compared to single-molecule CBD. Published in the Journal of Pharmacology & Pharmacy (February 2015), the article directly challenged one of the sacred cows of “Big Pharma” and traditional allopathic medicine — the belief that ‘crude” botanical preparations are inherently less effective than a purified formulation containing a single, well understood molecule with a clear structure and function.

Entitled “Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol,” the article is particularly noteworthy given the contribution of Lumir Hanus, one of the scientists responsible for the discovery of anandamide, the endogenous cannabinoid compound first identified in 1992.

Hanus and two colleagues from the Hebrew University of Jerusalem surveyed the scientific literature and found that during the past fifteen years several preclinical studies had focused on the anti-inflammatory effects of pure, single-molecule CBD using in vitro and in vivo animal models of various diseases including rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and diabetes.

These studies found that the administration of pure, single-molecule CBD resulted in a bell-shaped dose-response curve. This meant that when the dose of CBD exceeded a certain point its therapeutic effects went away.

“Healing was only observed when CBD was given within a very limited dose range, whereas no beneficial effect was achieved at either lower or higher doses,”

This characteristic of single-molecule CBD is a serious obstacle that limits its usefulness in a clinical context. In order to overcome this limitation, the Israeli team sought to compare whole plant extracts, which contained mostly CBD but also contained an array of minor cannabinoids and other constituents, with CBD alone. “The aim of the present study,” the authors explained, “was to find a CBD source that could eliminate the bell-shaped dose-response of purified CBD.”

The CBD-rich strain used by the researchers is called “Avidekel” and was obtained from Tikkun Olam, an Israeli medical marijuana producer. Avidekel contains only trace amounts of THC and therefore is not intoxicating. The Israeli researchers extracted CBD-rich oil which contained 17.9 percent CBD, 1.1 percent THC, 1.1 percent cannabichromene (CBC), 0.2 percent cannabigerol (CBG), and “traces” of cannabinol (CBN) and cannabidiol (CBDV). This “whole plant” extract was given to mice to evaluate its anti-inflammatory and pain relieving effects.

When compared to mice given pure CBD, those given the “whole plant”, CBD rich extract showed a direct, dose-dependent inhibition of pain, inflammation, and TNFa production. The “bell shaped” curve disapeared and instead “a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which [making] this plant medicine ideal for clinical uses.”

In addition, the Israeli researchers found that when using a CBD right, whole plant extract, a smaller amount of CBD was needed for significant pain relief compared to the much larger amount of pure CBD required to achieve the same effect. And where pure, single-molecule CBD experienced a rapid drop in efficacy after exceeding a specific dosage was administered, an “overdose” of whole plant CBD-rich extract did not undermine the direct dose response relationship. When a larger than optimal dose of the whole plant extract was administered, its effectiveness plateaued, suggesting that a therapeutic ceiling had been reached.

The Israeli study found that whole plant extracts are “superior over CBD [alone] for the treatment of inflammatory conditions.” The improved efficacy of whole plant extracts might be explained by the additive or synergistic interactions between CBD and the dozens of other minor cannabinoids and terpenes along with non-cannabinoid plant compounds like flavonoids.

“It is likely that other components in the extract synergize with CBD to achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD,”

The research also compared whole plant extracts with commercial painkillers and over-the-counter anti-inflammatory drugs. They found that both pure CBD and the CBD-rich whole plant extract exhibited greater anti-inflammatory effects than aspirin which registered a slight inhibitory effect on TNFa production. When compared to the strong inhibitory effect of pure CBD and the CBD-rich whole plant extract, this effect was negligible.  The key finding of this study is that CBD, in the presence of other active and essential components, improves the dose-response relationship and is further supported by recent reports documenting the anti-proliferative effect of cannabidiol on tumor cells.

To better understand how these two formulations differ, imagine being presented with two types of spaghetti sauce. In the first bowl, you’ll find a simple spaghetti sauce made out of pure tomatoes (CBD isolate). In the second bowl, you can find a more complex spaghetti sauce, containing roasted garlic and fragrant Italian herbs (full spectrum hemp oil). It’s clear that both bowls are holding spaghetti sauce – but the second recipe, which contains the ingredients of the first recipe and so much more, is more flavorful and interacts with one’s taste buds differently (also known as the “entourage effect”).

A lot of research has been done to isolate and characterize single constituents of traditional herbal medicine in order to better understand their therapeutic uses. However the recent data, which supports anecdotal evidence claiming that whole plant preparations are superior to single compound formulations, may lead to an entirely new generation of phyto-pharmaceuticals that can assist health challenges better than the alternatives and with no side effects. The therapeutic synergies observed in whole plant extracts appears to result in improved bioavailability, efficacy, and no adverse effects.

Oil and Water Do Not Mix
We all learned in grade school that water and oil do not mix.  If you are stubborn and must see this fact demonstrated, buy a bottle of CBD Oil or Full Spectrum Hemp Oil, pour it into a glass of water and neither will mix. They will indeed stay completely separated. Here is another factoid.  If you ingest an oil based supplement like CBD or full spectrum hemp oil, your body can only absorb at best, 6-10%. 

To get the greatest benefits, you need the greatest absorption.  It is ALL about the bioavailability of the product.Through our research, we have concluded it doesn’t make sense to spend money on a product that is oil because your body is just going to excrete 90%+ without using it at all.  We believe having products that have been made water soluble is the only answer.  Bottom-line, you get more bang for your buck and get way more actual results when you use a product that is clean, organic, cannabinoid rich and water soluble.

Looking for the real deal?  We have the best of the best and nothing else compares.  It all boils down to how effective the product is and our products are getting vastly better results for people than anything else out there. All products we offer are water soluble.  7 Full Spectrum Hemp Oil has a proven absorption rate of 85% while the Gold Standard in Full Spectrum Hemp Oil, UltraCell, boasts an incredible 99% absorption. 

Not only do our products have massive and immediate absorption, but they will work in your body for many hours and that is clinically proven.To experience the benefits of the whole plant, visit www.7LiquidGold.com and try our water soluble Full Spectrum Hemp Oil products yourself.

Our products are made from organically grown Industrial hemp and contains all of the 400+ compounds found naturally occurring in the plant. Our products have been made water soluble and  contain activated natural cannabinoids, terpenes flavonoids, vitamins and minerals which target the endocannabinoid system to promote a healthy inflammatory response while supporting the central nervous system.Just as important, every batch of hemp used to make this life changing blessing in a bottle is independently lab tested to confirm 0.00% THC in every single batch.

Which One is Right for Me?

Based on the comparison above, full spectrum hemp oil is way more effective than CBD isolate, making it highly recommended for people interested in holistic approaches to health challenges. Full Spectrum Hemp Oil is an extremely potent source of CBD (responsible for a large bulk of the oil’s cannabinoid profile).

The U.S Government has kept this amazing blessing away from us for 80+ years.  The only good in that realization is that has created an enormous opportunity for those who are looking to capitalize on an industry projected to grow by 700-800% over the next 2 years.  To learn how you too can position yourself to capitalize, check this out by CLICKING HERE>>>

Paul Crouse
Advanced Health & Nutrition, Inc.
Independent Zilis Ambassador